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"FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight." SELECT trial: 20% reduction in major adverse cardiovascular events

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The norleucine-4 modification eliminates the methionine residue susceptible to oxidation, while the D-phenylalanine-7 substitution enhances receptor binding affinity by constraining the peptide backbone in a conformation that favors MC1R interaction

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Some individuals might find weight reduction unsettling or experience concerns about their changing appearance, though there is limited evidence directly linking this to anxiety symptoms